Zolpidem Tartrate is a non-benzodiazepine, sedative-hypnotic, majorly used in various types of insomnia. Usual dosage regimen is 5mg, 2 times a day or 10mg, once daily having t1/2 2.5 hrs, undergoes hepatic first pass metabolism. Therefore in present study attempt has been done to formulate and evaluate the fast dissolving sublingual tablet of Zolpidem Tartrate. Tablets were prepared by wet granulation method using superdisintegrants, Sodium starch glycolate and Cross-povidone. Camphor was added in the formulation as a sublimating agent. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, and disintegration time and dissolution study. Among studied formations hardness was found in 3-3.5 kg/cm2 range and friability less than 1%.Weight variation taste complies with pharmacopoeias limits. Sublimation of Camphor from tablets resulted in better tablets as compared to the tablets prepared from granules that were exposing to vacuum. The systematic formulation approach helped in understanding the effect of formulation processing variables.
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